I'd like to get some discussion going about theme layout and maximizing AdSense income. I'll start by adding that I am NOT an AdSense expert, but I'd like to become one.
In other threads the Google hotspot map has been mentioned, but I'd like to ask for people's opinion on standard site layouts and how well they work for you. I've always used either two or three column designs, 2 col with sidebar navigation to the left, or 3 col content-sidebar-sidebar.
Are these the best or worst layouts? What works for you and drives AdSense income?