I saw an ad for Artisteer on one of Will's websites, and decided to take a visit. I've been fiddling around with the trial version, and I must say that it is absolutely excellent - and am almost tempted to go as far as recommending it. It is very easy to use (follows the same sort of interface as the Microsoft Office products), and can export as a regular HTML document, or into one of three different CMS's - Joomla, Drupal or WordPress.
At a price of $130 USD, it seems very reasonable. For every design that I have owned/own rights to, I have paid $60+, meaning that I would only need to create 2 designs to make it a worthwhile purchase. The only thing that I would like to see implemented in later releases... is some sort of way to make room for / place ads.