Newton relied upon the existing Scripture for prophecy, believing his interpretations would set the record straight in the face of what he considered to be, "so little understood".Though he would never write a cohesive body of work on Prophecy, Newton's beliefs would lead him to write several treatises on the subject, including an unpublished guide for prophetic interpretation entitled Rules for interpreting the words & language in Scripture. In this manuscript he details the necessary requirements for what he considered to be the proper interpretation of the Bible.

In his posthumously-published Observations upon the Prophecies of Daniel, and the Apocalypse of St. John, Newton expressed his belief that Bible prophecy would not be understood "until the time of the end", and that even then "none of the wicked shall understand". Referring to that as a future time ("the last age, the age of opening these things, be now approaching"), Newton also anticipated "the general preaching of the Gospel be approaching" and "the Gospel must first be preached in all nations before the great tribulation, and end of the world".

Over the years, a large amount of media attention and public interest has circulated regarding largely unknown and unpublished documents, evidently written by Isaac Newton, that indicate he believed the world could end in 2060 AD. While Newton also had many other possible dates e.g. 2034),and did not believe that the End of the World would take place in 2060.

To understand the reasoning behind the 2060 prediction an understanding of Newton's theological beliefs should be taken into account, particularly his nontrinitarian beliefs and those negative views he held about the Papacy. Both of these lay essential to his calculations, which are themselves based upon specific chronological dates which he believed had already transpired and had been prophesied in Revelation and Daniel.
Despite the dramatic nature of a prediction of the end of the world, Newton may not have been referring to the 2060 date as a destructive act resulting in the annihilation of the earth and its inhabitants, but rather one in which he believed the world was to be replaced with a new one based upon a transition to an era of divinely inspired peace. In Christian theology, this concept is often referred to as The Second Coming of Jesus Christ and the establishment of Paradise by The Kingdom of God on Earth.