Personally, I'm a fan of Joomla!, especially 1.5 which is vastly improved over 1.0.
If you're running a complex corporate intranet or some sort of portal with many different user roles and responsibilities, Drupal *may* be a better choice. I say "may" because the complication (and sometimes WRONGness) of Drupal can be difficult to overcome.
My $.02.
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